Common Inflammatory Mechanisms in Lewy Body Disease and Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Common inflammatory mechanisms in Lewy body disease and Alzheimer disease.
Cortical Lewy body disease as a cause of dementia has been recognized for more than 40 years. Only in the past 15 to 20 years, however, has the true frequency of this entity come to be appreciated, primarily because of the advent of sensitive and specific immunohistochemical diagnostic techniques. We now know that there is frequent and extensive overlap, both clinically and pathologically, betw...
متن کاملAlzheimer and Lewy body pathology or Creutzfeldt-Jakob disease.
The objective of this work is to describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease. Methods used were clinical description with laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies and details on neuropatholog...
متن کاملAlterations in Olfaction during Alzheimer Disease, Parkinson Disease and Lewy Body Disease
Increasing interest is being shown in the link between olfaction, a complex sensory system, and cognition, particularly in the elderly. Olfaction is known to affect cognitive abilities and mood. In this article, we consider the impairment of olfactory function due to Alzheimer disease (AD), Parkinson disease (PD) and Lewy body disease (LBD), through pathological changes in the peripheral and ce...
متن کاملLewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype.
BACKGROUND The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood. OBJECTIVE To examine LBP in the brainstem, limbic cortex, and neocortex of a large number of familial AD cases with mutations in 2 presenilin (PSEN) genes. METHODS Twenty-five familial AD cases with 9 known PSEN 1 mutations and 14 familial AD cases ...
متن کاملCortical Lewy body disease.
C ortical Lewy body disease is a pathological observation rather than a distinct clinicopathological entity. Cortical Lewy bodies (CLB) are typically found in Parkinson’s disease and dementia with Lewy bodies (DLB), although they may also occur in other neurological disorders. Unlike their brain stem counterparts, CLB are less distinctive and are poorly visualised using conventional histochemic...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2007
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0b013e31812503e1